Anti-FGB/Fibrinogen beta antibody [8E5#] (STJA0019254)

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STJA0019254
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Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Mouse monoclonal antibody anti-Fibrinogen Beta Chain Cleaved Into-Fibrinopeptide B-Fibrinogen Beta Chain is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : 8E5#
Conjugation: Unconjugated
Isotype: IgG1
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Concentration: 1 mg/mL
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol: FGB
Gene ID: 2244
Uniprot ID: FIBB_HUMAN
Post Translational Modifications Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Protein Name Fibrinogen Beta Chain Cleaved Into - Fibrinopeptide B - Fibrinogen Beta Chain
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-1236974
Reactome: R-HSA-140875
Reactome: R-HSA-166058
Reactome: R-HSA-216083
Reactome: R-HSA-354192
Reactome: R-HSA-354194
Reactome: R-HSA-372708
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Reactome: R-HSA-5674135
Reactome: R-HSA-5686938
Reactome: R-HSA-6802946
Reactome: R-HSA-6802948
Reactome: R-HSA-6802952
Reactome: R-HSA-6802955
Reactome: R-HSA-9649948
Reactome: R-HSA-9656223
Cellular Localisation Secreted
Alternative Antibody Names Anti-Fibrinogen Beta Chain Cleaved Into - Fibrinopeptide B - Fibrinogen Beta Chain antibody
Anti-FGB antibody

Information sourced from Uniprot.org