| Tissue Specificity | Widely expressed. Detected in adult colon epithelium (at protein level). Expressed in melanocytes (at protein level). |
| Post Translational Modifications | Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK. |
| Function | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. |
| Protein Name | Tyrosine-Protein Kinase Fes/FpsFeline Sarcoma/Fujinami Avian Sarcoma Oncogene HomologProto-Oncogene C-FesProto-Oncogene C-FpsP93c-Fes |
| Database Links | Reactome: R-HSA-1433557Reactome: R-HSA-399954Reactome: R-HSA-399955Reactome: R-HSA-399956 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleGolgi ApparatusCell JunctionFocal AdhesionDistributed Throughout The Cytosol When The Kinase Is Not ActivatedAssociation With Microtubules Requires Activation Of The Kinase ActivityShuttles Between Focal Adhesions And Cell-Cell Contacts In Epithelial CellsRecruited To The Lateral Cell Membrane In Polarized Epithelial Cells By Interaction With Phosphorylated EzrDetected At Tubular Membrane Structures In The Cytoplasm And At The Cell Periphery |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Fes/Fps antibodyAnti-Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog antibodyAnti-Proto-Oncogene C-Fes antibodyAnti-Proto-Oncogene C-Fps antibodyAnti-P93c-Fes antibodyAnti-FES antibodyAnti-FPS antibody |
Information sourced from Uniprot.org
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