| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Fermitin family homolog 3 (52-102 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FERMT3 |
| Gene ID: | 83706 |
| Uniprot ID: | URP2_HUMAN |
| Immunogen Region: | 52-102 aa |
| Specificity: | URP2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein at the amino acid range 52-102 |
| Function | Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. |
| Protein Name | Fermitin Family Homolog 3Kindlin-3Mig2-Like ProteinUnc-112-Related Protein 2 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | Cell ProjectionPodosomePresent In The F-Actin Surrounding Ring Structure Of PodosomesWhich Are Specialized Adhesion Structures Of Hematopoietic Cells |
| Alternative Antibody Names | Anti-Fermitin Family Homolog 3 antibodyAnti-Kindlin-3 antibodyAnti-Mig2-Like Protein antibodyAnti-Unc-112-Related Protein 2 antibodyAnti-FERMT3 antibodyAnti-KIND3 antibodyAnti-MIG2B antibodyAnti-URP2 antibody |
Information sourced from Uniprot.org