Anti-FERMT1 antibody (STJA0007429)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Kindlin 1
General Information
| Short Description | Rabbit polyclonal anti-Fermitin family homolog 1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FERMT1 |
| Gene ID | 55612 |
| Uniprot ID | FERM1_HUMAN |
| Immunogen | Synthesized peptide derived from human Kindlin 1 |
| Specificity | This antibody detects endogenous levels of Kindlin 1 at Human, Mouse |
Additional Info
| Function | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. |
| Protein Name | Fermitin Family Homolog 1KindlerinKindlin Syndrome ProteinKindlin-1Unc-112-Related Protein 1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionFocal AdhesionCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideConstituent Of Focal AdhesionsLocalized At The Basal Aspect Of Skin KeratinocytesClose To The Cell MembraneColocalizes With Filamentous ActinUpon Tgfb1 TreatmentIt Localizes To Membrane Ruffles |
| Alternative Antibody Names | Anti-Fermitin Family Homolog 1 antibodyAnti-Kindlerin antibodyAnti-Kindlin Syndrome Protein antibodyAnti-Kindlin-1 antibodyAnti-Unc-112-Related Protein 1 antibodyAnti-FERMT1 antibodyAnti-C20orf42 antibodyAnti-KIND1 antibodyAnti-URP1 antibody |
Information sourced from Uniprot.org