| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Fermitin family homolog 1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FERMT1 |
| Gene ID: |
55612 |
| Uniprot ID: |
FERM1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of Kindlin 1 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human Kindlin 1 |
| Function | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. |
| Protein Name | Fermitin Family Homolog 1KindlerinKindlin Syndrome ProteinKindlin-1Unc-112-Related Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionFocal AdhesionCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideConstituent Of Focal AdhesionsLocalized At The Basal Aspect Of Skin KeratinocytesClose To The Cell MembraneColocalizes With Filamentous ActinUpon Tgfb1 TreatmentIt Localizes To Membrane Ruffles |
| Alternative Antibody Names | Anti-Fermitin Family Homolog 1 antibodyAnti-Kindlerin antibodyAnti-Kindlin Syndrome Protein antibodyAnti-Kindlin-1 antibodyAnti-Unc-112-Related Protein 1 antibodyAnti-FERMT1 antibodyAnti-C20orf42 antibodyAnti-KIND1 antibodyAnti-URP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
