| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Low affinity immunoglobulin gamma Fc region receptor II-b (141-190 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FCGR2B |
| Gene ID: |
2213 |
| Uniprot ID: |
FCG2B_HUMAN |
| Immunogen Region: |
141-190 aa |
| Specificity: |
CD32-B/C Polyclonal Antibody detects endogenous levels of CD32-B/C protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human FCGR2B/C at the amino acid range 141-190 |
| Post Translational Modifications | Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. |
| Function | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-BIgg Fc Receptor Ii-BCdw32Fc-Gamma Rii-BFc-Gamma-RiibFcrii-BCd Antigen Cd32 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B antibodyAnti-Igg Fc Receptor Ii-B antibodyAnti-Cdw32 antibodyAnti-Fc-Gamma Rii-B antibodyAnti-Fc-Gamma-Riib antibodyAnti-Fcrii-B antibodyAnti-Cd Antigen Cd32 antibodyAnti-FCGR2B antibodyAnti-CD32 antibodyAnti-FCG2 antibodyAnti-IGFR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
