| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FCGR1A (16-288) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FCGR1A |
| Gene ID: |
2209 |
| Uniprot ID: |
FCGR1_HUMAN |
| Immunogen Region: |
16-288 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 16-288 of human CD64 (NP_000557.1). |
| Immunogen Sequence: |
QVDTTKAVITLQPPWVSVFQ EETVTLHCEVLHLPGSSSTQ WFLNGTATQTSTPSYRITSA SVNDSGEYRCQRGLSGRSDP IQLEIHRGWLLLQVSSRVFT EGEPLALRCHAWKDKLVYNV LYYRNGKAFKFFHWNSNLTI LKTNISHNGTYHCSGMGKHR YTSAGISVTVKELFPAPVLN ASVTSPLLEGNLVTLSCETK LLLQRPGLQLYFSFYMGSKT LRGRNTSSEYQILTARRED |
| Tissue Specificity | Monocyte/macrophage specific. |
| Post Translational Modifications | Phosphorylated on serine residues. |
| Function | High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells. |
| Protein Name | High Affinity Immunoglobulin Gamma Fc Receptor IIgg Fc Receptor IFc-Gamma RiFcriFc-Gamma RiaFcgammariaCd Antigen Cd64 |
| Database Links | Reactome: R-HSA-1236978Reactome: R-HSA-198933Reactome: R-HSA-2029481Reactome: R-HSA-2029482Reactome: R-HSA-2029485Reactome: R-HSA-877300Reactome: R-HSA-9664323 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinStabilized At The Cell Membrane Through Interaction With Fcer1g |
| Alternative Antibody Names | Anti-High Affinity Immunoglobulin Gamma Fc Receptor I antibodyAnti-Igg Fc Receptor I antibodyAnti-Fc-Gamma Ri antibodyAnti-Fcri antibodyAnti-Fc-Gamma Ria antibodyAnti-Fcgammaria antibodyAnti-Cd Antigen Cd64 antibodyAnti-FCGR1A antibodyAnti-FCG1 antibodyAnti-FCGR1 antibodyAnti-IGFR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
