| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5017RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FCER2 |
| Gene ID: | 2208 |
| Uniprot ID: | FCER2_HUMAN |
| Immunogen Region: | 48-321 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 48-321 of human CD23 (NP_001993.2). |
| Immunogen Sequence: | DTTQSLKQLEERAARNVSQV SKNLESHHGDQMAQKSQSTQ ISQELEELRAEQQRLKSQDL ELSWNLNGLQADLSSFKSQE LNERNEASDLLERLREEVTK LRMELQVSSGFVCNTCPEKW INFQRKCYYFGKGTKQWVHA RYACDDMEGQLVSIHSPEEQ DFLTKHASHTGSWIGLRNLD LKGEFIWVDGSHVDYSNWAP GEPTSRSQGEDCVMMRGSGR WNDAFCDRKLGAWVCDRLA |
| Tissue Specificity | Detected in urine (at protein level). |
| Post Translational Modifications | N- and O-glycosylated. The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding. |
| Function | Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway. |
| Protein Name | Low Affinity Immunoglobulin Epsilon Fc Receptor Blast-2 C-Type Lectin Domain Family 4 Member J Fc-Epsilon-Rii Immunoglobulin E-Binding Factor Lymphocyte Ige Receptor Cd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form |
| Database Links | Reactome: R-HSA-2197563 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein Lipid-Anchor Secreted Also Exists As A Soluble Excreted Form Scd23 |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Epsilon Fc Receptor antibody Anti-Blast-2 antibody Anti-C-Type Lectin Domain Family 4 Member J antibody Anti-Fc-Epsilon-Rii antibody Anti-Immunoglobulin E-Binding Factor antibody Anti-Lymphocyte Ige Receptor antibody Anti-Cd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form antibody Anti-FCER2 antibody Anti-CD23A antibody Anti-CLEC4J antibody Anti-FCE2 antibody Anti-IGEBF antibody |
Information sourced from Uniprot.org