Anti-Fcer1a antibody [MAR-1] {FITC} (STJA0002042)
SPECIFICATIONS
ClonalityMonoclonal
HostArmenian Hamster
ConjugationFITC
IsotypeIgG
General Information
| Short Description | Armenian Hamster monoclonal anti-High affinity immunoglobulin epsilon receptor subunit alpha for use in FC in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Armenian Hamster |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MAR-1 |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 5 Mu L/Test |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | Fcer1a |
| Gene ID | 14125 |
| Uniprot ID | FCERA_MOUSE |
Additional Info
| Tissue Specificity | Expressed in bone marrow mast cells, as well as in the pineal gland at night. |
| Function | High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit AlphaFc-Epsilon Ri-AlphaFceriIge Fc Receptor Subunit Alpha |
| Database Links | Reactome: R-MMU-2454202Reactome: -MMU-2730905Reactome: -MMU-2871796Reactome: -MMU-2871809Reactome: -MMU-2871837 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha antibodyAnti-Fc-Epsilon Ri-Alpha antibodyAnti-Fceri antibodyAnti-Ige Fc Receptor Subunit Alpha antibodyAnti-Fcer1a antibodyAnti-Fce1a antibody |
Information sourced from Uniprot.org