| Short Description : | Rabbit monoclonal High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha (26-205 aa) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4932RM |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:7000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FCER1A |
| Gene ID: | 2205 |
| Uniprot ID: | FCERA_HUMAN |
| Immunogen Region: | 26-205 aa |
| Immunogen Sequence: | VPQKPKVSLNPPWNRIFKGE NVTLTCNGNNFFEVSSTKWF HNGSLSEETNSSLNIVNAKF EDSGEYKCQHQQVNESEPVY LEVFSDWLLLQASAEVVMEG QPLFLRCHGWRNWDVYKVIY YKDGEALKYWYENHNISITN ATVEDSGTYYCTGKVWQLDY ESEPLNITVIKAPREKYWLQ |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-205 of human FceR1 alpha. (NP_001992.1). |
| Tissue Specificity | Expressed in eosinophils. |
| Function | High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit AlphaFc-Epsilon Ri-AlphaFceriIge Fc Receptor Subunit Alpha |
| Database Links | Reactome: R-HSA-2454202Reactome: R-HSA-2730905Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-2871837 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha antibodyAnti-Fc-Epsilon Ri-Alpha antibodyAnti-Fceri antibodyAnti-Ige Fc Receptor Subunit Alpha antibodyAnti-FCER1A antibodyAnti-FCE1A antibody |
Information sourced from Uniprot.org
