| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FBXW8 (500-598) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FBXW8 |
| Gene ID: |
26259 |
| Uniprot ID: |
FBXW8_HUMAN |
| Immunogen Region: |
500-598 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 500-598 of human FBXW8 (NP_699179.2). |
| Immunogen Sequence: |
WDYRMNQKLWEVYSGHPVQH ISFSSHSLITANVPYQTVMR NADLDSFTTHRRHRGLIRAY EFAVDQLAFQSPLPVCRSSC DAMATHYYDLALAFPYNHV |
| Function | Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions. |
| Protein Name | F-Box/Wd Repeat-Containing Protein 8F-Box And Wd-40 Domain-Containing Protein 8F-Box Only Protein 29 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmPerinuclear RegionGolgi ApparatusColocalizes With Cul7 At The Golgi Apparatus In Neurons |
| Alternative Antibody Names | Anti-F-Box/Wd Repeat-Containing Protein 8 antibodyAnti-F-Box And Wd-40 Domain-Containing Protein 8 antibodyAnti-F-Box Only Protein 29 antibodyAnti-FBXW8 antibodyAnti-FBW6 antibodyAnti-FBW8 antibodyAnti-FBX29 antibodyAnti-FBXO29 antibodyAnti-FBXW6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
