| Function | Substrate-recognition component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions. |
| Protein Name | F-Box/Wd Repeat-Containing Protein 8F-Box And Wd-40 Domain-Containing Protein 8F-Box Only Protein 29 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmPerinuclear RegionGolgi ApparatusColocalizes With Cul7 At The Golgi Apparatus In Neurons |
| Alternative Antibody Names | Anti-F-Box/Wd Repeat-Containing Protein 8 antibodyAnti-F-Box And Wd-40 Domain-Containing Protein 8 antibodyAnti-F-Box Only Protein 29 antibodyAnti-FBXW8 antibodyAnti-FBW6 antibodyAnti-FBW8 antibodyAnti-FBX29 antibodyAnti-FBXO29 antibodyAnti-FBXW6 antibody |
Information sourced from Uniprot.org
