| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-F-box only protein 43 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FBXO43 |
| Gene ID: | 286151 |
| Uniprot ID: | FBX43_HUMAN |
| Specificity: | This antibody detects endogenous levels of FBXO43 at Human, Rat |
| Immunogen: | Synthesized peptide derived from human FBXO43 |
| Post Translational Modifications | Phosphorylated on Ser-76, Thr-234 and Ser-334 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation. Ubiquitinated in response to calcium, which promotes proteasomal degradation. |
| Function | Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. |
| Protein Name | F-Box Only Protein 43Endogenous Meiotic Inhibitor 2 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-F-Box Only Protein 43 antibodyAnti-Endogenous Meiotic Inhibitor 2 antibodyAnti-FBXO43 antibodyAnti-EMI2 antibody |
Information sourced from Uniprot.org
