| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FBXO38 |
| Gene ID: | 81545 |
| Uniprot ID: | FBX38_HUMAN |
| Immunogen Region: | 640-943 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 640-943 of human FBXO38 (Q6PIJ6). |
| Immunogen Sequence: | VSGKGKTPLRKRYNSHQMGQ SKQFPLEESSCEKGCQVTSE QIKADMKAARDIPEKKKNKD VYPSCSSTTASTVGNSSSHN TASQSPDFVRTVNSGGSSEP SPTEVDVSRQCACSPGGSED SEAMEEGDAESSVCPRCCCH RPQESQRRTSRCSDEERPST SRACVVNGPDGTRSAFSFRT LPQGGSSGPAHDERTNGSGS GATGEDRRGSSQPESCDVQS NEDYPRRPLTRARSRLSHV |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity. Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1.the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival. May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination. |
| Protein Name | F-Box Only Protein 38 |
| Cellular Localisation | CytoplasmCytosolNucleusAccumulates Predominantly In The CytosolExported From The Nucleus In A Xpo1/Crm1-Dependent Manner |
| Alternative Antibody Names | Anti-F-Box Only Protein 38 antibodyAnti-FBXO38 antibodyAnti-SP329 antibody |
Information sourced from Uniprot.org