Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-F-box only protein 31 (17-67) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:1000-2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
FBXO31 |
Gene ID: |
79791 |
Uniprot ID: |
FBX31_HUMAN |
Immunogen Region: |
17-67 |
Specificity: |
This antibody detects endogenous levels of human FBX31 |
Immunogen: |
Synthesized peptide derived from human FBX31 AA range: 17-67 |
Post Translational Modifications | Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization. |
Function | Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. |
Protein Name | F-Box Only Protein 31 |
Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
Alternative Antibody Names | Anti-F-Box Only Protein 31 antibodyAnti-FBXO31 antibodyAnti-FBX14 antibodyAnti-FBX31 antibodyAnti-PP2386 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance