| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FBXO10 (1-180) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FBXO10 |
| Gene ID: |
26267 |
| Uniprot ID: |
FBX10_HUMAN |
| Immunogen Region: |
1-180 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human FBXO10 (NP_036298.2). |
| Immunogen Sequence: |
MEAGGLPLELWRMILAYLHL PDLGRCSLVCRAWYELILSL DSTRWRQLCLGCTECRHPNW PNQPDVEPESWREAFKQHYL ASKTWTKNALDLESSICFSL FRRRRERRTLSVGPGREFDS LGSALAMASLYDRIVLFPGV YEEQGEIILKVPVEIVGQGK LGEVALLASIDQHCSTTRLC |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation. Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling. |
| Protein Name | F-Box Only Protein 10 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-F-Box Only Protein 10 antibodyAnti-FBXO10 antibodyAnti-FBX10 antibodyAnti-PRMT11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
