| Short Description : | Goat polyclonal antibody anti-FBXL3 (N-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications: | Pep-ELISA/WB/IHC |
| Host: | Goat |
| Reactivity: | Human/Mouse/Rat/Dog/Pig |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 50-55kDa band observed in Human Adipose lysates (calculated MW of 48.7kDa according to NP_036290.1). Recommended concentration: 1-3µg/ml.IHC: Paraffin embedded Human Thyroi |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | FBXL3 |
| Gene ID: | 26224 |
| Uniprot ID: | FBXL3_HUMAN |
| Accession Number: | NP_036290.1 |
| Immunogen Region: | N-Term |
| Immunogen Sequence: | KRGGRDSDRNSSEE |
| Post Translational Modifications | Undergoes autophagy-mediated degradation in the liver in a time-dependent manner. |
| Function | Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. |
| Protein Name | F-Box/Lrr-Repeat Protein 3F-Box And Leucine-Rich Repeat Protein 3aF-Box/Lrr-Repeat Protein 3a |
| Database Links | Reactome: R-HSA-390471Reactome: R-HSA-400253Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasmPredominantly Nuclear |
| Alternative Antibody Names | Anti-F-Box/Lrr-Repeat Protein 3 antibodyAnti-F-Box And Leucine-Rich Repeat Protein 3a antibodyAnti-F-Box/Lrr-Repeat Protein 3a antibodyAnti-FBXL3 antibodyAnti-FBL3A antibodyAnti-FBXL3A antibody |
Information sourced from Uniprot.org
