| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FBXL12 (1-326) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FBXL12 |
| Gene ID: |
54850 |
| Uniprot ID: |
FXL12_HUMAN |
| Immunogen Region: |
1-326 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human FBXL12 (NP_060173.1). |
| Immunogen Sequence: |
MATLVELPDSVLLEIFSYLP VRDRIRISRVCHRWKRLVDD RWLWRHVDLTLYTMRPKVMW HLLRRYMASRLHSLRMGGYL FSGSQAPQLSPALLRALGQK CPNLKRLCLHVADLSMVPIT SLPSTLRTLELHSCEISMAW LHKQQDPTVLPLLECIVLDR VPAFRDEHLQGLTRFRALRS LVLGGTYRVTETGLDAGLQE LSYLQRLEVLGCTLSADSTL LAISRHLRDVRKIRLTVRG |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia. |
| Protein Name | F-Box/Lrr-Repeat Protein 12F-Box And Leucine-Rich Repeat Protein 12F-Box Protein Fbl12 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-F-Box/Lrr-Repeat Protein 12 antibodyAnti-F-Box And Leucine-Rich Repeat Protein 12 antibodyAnti-F-Box Protein Fbl12 antibodyAnti-FBXL12 antibodyAnti-FBL12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
