Anti-FASTK antibody (361-410 aa) (STJ93043)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human FAST at the amino acid range 361-410
General Information
| Short Description | Rabbit polyclonal anti-Fas-activated serine/threonine kinase (361-410 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FASTK |
| Gene ID | 10922 |
| Uniprot ID | FASTK_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human FAST at the amino acid range 361-410 |
| Immunogen Region | 361-410 aa |
| Specificity | FAST Polyclonal Antibody detects endogenous levels of FAST protein. |
Additional Info
| Post Translational Modifications | Autophosphorylated on serine/threonine residues. Activated by dephosphorylation. |
| Function | Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. Isoform 4: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels. |
| Protein Name | Fas-Activated Serine/Threonine KinaseFast Kinase |
| Database Links | Reactome: R-HSA-9837092 Q14296-4 |
| Cellular Localisation | Isoform 4: Mitochondrion MatrixColocalizes With Mitochondrial Rna Granules |
| Alternative Antibody Names | Anti-Fas-Activated Serine/Threonine Kinase antibodyAnti-Fast Kinase antibodyAnti-FASTK antibody |
Information sourced from Uniprot.org