| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FASTK |
| Gene ID: | 10922 |
| Uniprot ID: | FASTK_HUMAN |
| Immunogen Region: | 360-549 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-549 of human FASTK (NP_006703.1). |
| Immunogen Sequence: | LLDTAVELELPGYRGPRLPR RQQVPIFPQPLITDRARCKY SHKDIVAEGLRQLLGEEKYR QDLTVPPGYCTDFLLCASSS GAVLPVRTQDPFLPYPPRSC PQGQAASSATTRDPAQRVVL VLRERWHFCRDGRVLLGSRA LRERHLGLMGYQLLPLPFEE LESQRGLPQLKSYLRQKLQA LGLRWGPEGG |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Autophosphorylated on serine/threonine residues. Activated by dephosphorylation. |
| Function | Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. Isoform 4: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels. |
| Protein Name | Fas-Activated Serine/Threonine Kinase Fast Kinase |
| Database Links | Reactome: R-HSA-9837092 Q14296-4 |
| Cellular Localisation | Isoform 4: Mitochondrion Matrix Colocalizes With Mitochondrial Rna Granules |
| Alternative Antibody Names | Anti-Fas-Activated Serine/Threonine Kinase antibody Anti-Fast Kinase antibody Anti-FASTK antibody |
Information sourced from Uniprot.org