| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FASTK (360-549) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FASTK |
| Gene ID: |
10922 |
| Uniprot ID: |
FASTK_HUMAN |
| Immunogen Region: |
360-549 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 360-549 of human FASTK (NP_006703.1). |
| Immunogen Sequence: |
LLDTAVELELPGYRGPRLPR RQQVPIFPQPLITDRARCKY SHKDIVAEGLRQLLGEEKYR QDLTVPPGYCTDFLLCASSS GAVLPVRTQDPFLPYPPRSC PQGQAASSATTRDPAQRVVL VLRERWHFCRDGRVLLGSRA LRERHLGLMGYQLLPLPFEE LESQRGLPQLKSYLRQKLQA LGLRWGPEGG |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Autophosphorylated on serine/threonine residues. Activated by dephosphorylation. |
| Function | Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. Isoform 4: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels. |
| Protein Name | Fas-Activated Serine/Threonine KinaseFast Kinase |
| Cellular Localisation | Isoform 4: Mitochondrion MatrixColocalizes With Mitochondrial Rna Granules |
| Alternative Antibody Names | Anti-Fas-Activated Serine/Threonine Kinase antibodyAnti-Fast Kinase antibodyAnti-FASTK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
