Anti-Fascin antibody [IM20] (STJ16101740)

Anti-Fascin antibody [IM20] (STJ16101740)

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STJ16101740-1
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Host: Mouse
Applications: IHC-P/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Fascin is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : IM20
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Tissue culture supernatant with 15 mM Sodium azide
Dilution Range: IHC-P 1:200-1:400
WB 1:100-1:200
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: FSCN1
Gene ID: 6624
Uniprot ID: FSCN1_HUMAN
Immunogen: Prokaryotic recombinant protein corresponding to the C-terminal region of the fascin molecule.
Tissue Specificity Ubiquitous.
Post Translational Modifications Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF.
Function Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF.
Protein Name Fascin
55 Kda Actin-Bundling Protein
Singed-Like Protein
P55
Database Links Reactome: R-HSA-6785807
Cellular Localisation Cytoplasm
Cytosol
Cell Cortex
Cytoskeleton
Stress Fiber
Cell Projection
Filopodium
Invadopodium
Microvillus
Cell Junction
Colocalized With Rufy3 And F-Actin At Filipodia Of The Axonal Growth Cone
Colocalized With Dbn1 And F-Actin At The Transitional Domain Of The Axonal Growth Cone
Alternative Antibody Names Anti-Fascin antibody
Anti-55 Kda Actin-Bundling Protein antibody
Anti-Singed-Like Protein antibody
Anti-P55 antibody
Anti-FSCN1 antibody
Anti-FAN1 antibody
Anti-HSN antibody
Anti-SNL antibody

Information sourced from Uniprot.org

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