![Anti-Fascin antibody [IM20] (STJ16101740)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/152246/347096/STJ16101740_1__64986.1681999361.jpg?c=1 "Anti-Fascin antibody [IM20] (STJ16101740)")
![Anti-Fascin antibody [IM20] (STJ16101740)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/152246/347096/STJ16101740_1__64986.1681999361.jpg?c=1 "Anti-Fascin antibody [IM20] (STJ16101740)")
| Host: | Mouse |
| Applications: | IHC-P/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Fascin is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | IM20 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | Tissue culture supernatant with 15 mM Sodium azide |
| Dilution Range: | IHC-P 1:200-1:400 WB 1:100-1:200 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | FSCN1 |
| Gene ID: | 6624 |
| Uniprot ID: | FSCN1_HUMAN |
| Immunogen: | Prokaryotic recombinant protein corresponding to the C-terminal region of the fascin molecule. |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF. |
| Function | Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF. |
| Protein Name | Fascin 55 Kda Actin-Bundling Protein Singed-Like Protein P55 |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Cytoplasm Cytosol Cell Cortex Cytoskeleton Stress Fiber Cell Projection Filopodium Invadopodium Microvillus Cell Junction Colocalized With Rufy3 And F-Actin At Filipodia Of The Axonal Growth Cone Colocalized With Dbn1 And F-Actin At The Transitional Domain Of The Axonal Growth Cone |
| Alternative Antibody Names | Anti-Fascin antibody Anti-55 Kda Actin-Bundling Protein antibody Anti-Singed-Like Protein antibody Anti-P55 antibody Anti-FSCN1 antibody Anti-FAN1 antibody Anti-HSN antibody Anti-SNL antibody |
Information sourced from Uniprot.org