| Host: |
Mouse |
| Applications: |
IHC-P/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Fascin is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
IM20 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1k |
| Formulation: |
Tissue culture supernatant with 15 mM Sodium azide |
| Dilution Range: |
IHC-P 1:200-1:400WB 1:100-1:200 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
FSCN1 |
| Gene ID: |
6624 |
| Uniprot ID: |
FSCN1_HUMAN |
| Immunogen: |
Prokaryotic recombinant protein corresponding to the C-terminal region of the fascin molecule. |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF. |
| Function | Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF. |
| Protein Name | Fascin55 Kda Actin-Bundling ProteinSinged-Like ProteinP55 |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | CytoplasmCytosolCell CortexCytoskeletonStress FiberCell ProjectionFilopodiumInvadopodiumMicrovillusCell JunctionColocalized With Rufy3 And F-Actin At Filipodia Of The Axonal Growth ConeColocalized With Dbn1 And F-Actin At The Transitional Domain Of The Axonal Growth Cone |
| Alternative Antibody Names | Anti-Fascin antibodyAnti-55 Kda Actin-Bundling Protein antibodyAnti-Singed-Like Protein antibodyAnti-P55 antibodyAnti-FSCN1 antibodyAnti-FAN1 antibodyAnti-HSN antibodyAnti-SNL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Anti-Fascin antibody [55-k2] (STJ16100367)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/149084/346701/STJ16100367_1__06161.1681998786.jpg?c=1 "Anti-Fascin antibody [55-k2] (STJ16100367)")
