| Post Translational Modifications | Phosphorylated.hyperphosphorylated in response to genotoxic stress. |
| Function | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA. |
| Protein Name | Fanconi Anemia Group M ProteinProtein FacmAtp-Dependent Rna Helicase FancmFanconi Anemia-Associated Polypeptide Of 250 KdaFaap250Protein Hef Ortholog |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-9833482 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Fanconi Anemia Group M Protein antibodyAnti-Protein Facm antibodyAnti-Atp-Dependent Rna Helicase Fancm antibodyAnti-Fanconi Anemia-Associated Polypeptide Of 250 Kda antibodyAnti-Faap250 antibodyAnti-Protein Hef Ortholog antibodyAnti-FANCM antibodyAnti-KIAA1596 antibody |
Information sourced from Uniprot.org
