| Function | Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps. |
| Protein Name | Fanconi-Associated Nuclease 1Fancd2/Fanci-Associated Nuclease 1Hfan1Myotubularin-Related Protein 15 |
| Database Links | Reactome: R-HSA-6783310 |
| Cellular Localisation | NucleusLocalizes At Sites Of Dna Damage Following Recruitment By Monoubiquitinated Fancd2Localizes To Stalled Replication Forks Via Its Ubz4-Type Zinc Finger |
| Alternative Antibody Names | Anti-Fanconi-Associated Nuclease 1 antibodyAnti-Fancd2/Fanci-Associated Nuclease 1 antibodyAnti-Hfan1 antibodyAnti-Myotubularin-Related Protein 15 antibodyAnti-FAN1 antibodyAnti-KIAA1018 antibodyAnti-MTMR15 antibody |
Information sourced from Uniprot.org
