| Short Description : | Rabbit polyclonal FAM129B (447-746) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NIBAN2 |
| Gene ID: | 64855 |
| Uniprot ID: | NIBA2_HUMAN |
| Immunogen Region: | 447-746 |
| Immunogen Sequence: | TFETLLHQELGKGPTKEELC KSIQRVLERVLKKYDYDSSS VRKRFFREALLQISIPFLLK KLAPTCKSELPRFQELIFED FARFILVENTYEEVVLQTVM KDILQAVKEAAVQRKHNLYR DSMVMHNSDPNLHLLAEGAP IDWGEEYSNSGGGGSPSPST PESATLSEKRRRAKQVVSVV QDEEVGLPFEASPESPPPAS PDGVTEIRGLLAQGLRPESP PPAGPLLNGAPAGESPQPK |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 447-746 of human FAM129B (NP_073744.2). |
| Post Translational Modifications | Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane. As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases. |
| Function | May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. |
| Protein Name | Protein Niban 2Meg-3Melanoma Invasion By ErkMinervaNiban-Like Protein 1Protein Fam129b |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolCell JunctionAdherens JunctionMembraneLipid-AnchorIn Exponentially Growing CellsExclusively CytoplasmicCell Membrane Localization Is Observed When Cells Reach Confluency And During TelophaseIn Melanoma CellsTargeting To The Plasma Membrane May Be Impaired By C-Terminal Phosphorylation |
| Alternative Antibody Names | Anti-Protein Niban 2 antibodyAnti-Meg-3 antibodyAnti-Melanoma Invasion By Erk antibodyAnti-Minerva antibodyAnti-Niban-Like Protein 1 antibodyAnti-Protein Fam129b antibodyAnti-NIBAN2 antibodyAnti-C9orf88 antibodyAnti-FAM129B antibody |
Information sourced from Uniprot.org
