| Function | Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory. Plays a role in the actin and microtubule cytoskeleton organization.negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development. |
| Protein Name | Actin-Associated Protein Fam107aDown-Regulated In Renal Cell Carcinoma 1Protein Tu3a |
| Cellular Localisation | NucleusCytoplasmCytoskeletonStress FiberCell JunctionFocal AdhesionCell ProjectionRuffle MembraneSynapseColocalizes With F-Actin And Commd1 In The NucleusColocalizes With Map1a Along Actin Stress Fibers And Membrane Ruffles |
| Alternative Antibody Names | Anti-Actin-Associated Protein Fam107a antibodyAnti-Down-Regulated In Renal Cell Carcinoma 1 antibodyAnti-Protein Tu3a antibodyAnti-FAM107A antibodyAnti-DRR1 antibodyAnti-TU3A antibody |
Information sourced from Uniprot.org
