| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FAM107A (1-144) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FAM107A |
| Gene ID: |
11170 |
| Uniprot ID: |
F107A_HUMAN |
| Immunogen Region: |
1-144 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-144 of human FAM107A (NP_009108.1). |
| Immunogen Sequence: |
MYSEIQRERADIGGLMARPE YREWNPELIKPKKLLNPVKA SRSHQELHRELLMNHRRGLG VDSKPELQRVLEHRRRNQLI KKKKEELEAKRLQCPFEQEL LRRQQRLNQLEKPPEKEEDH APEFIKVRENLRRIATLTSE EREL |
| Tissue Specificity | Widely expressed. Expressed in neurons. Expressed in malignant glial tumors. Expression is reduced or absent in a number of cancer cell lines. |
| Function | Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory. Plays a role in the actin and microtubule cytoskeleton organization.negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development. |
| Protein Name | Actin-Associated Protein Fam107aDown-Regulated In Renal Cell Carcinoma 1Protein Tu3a |
| Cellular Localisation | NucleusCytoplasmCytoskeletonStress FiberCell JunctionFocal AdhesionCell ProjectionRuffle MembraneSynapseColocalizes With F-Actin And Commd1 In The NucleusColocalizes With Map1a Along Actin Stress Fibers And Membrane Ruffles |
| Alternative Antibody Names | Anti-Actin-Associated Protein Fam107a antibodyAnti-Down-Regulated In Renal Cell Carcinoma 1 antibodyAnti-Protein Tu3a antibodyAnti-FAM107A antibodyAnti-DRR1 antibodyAnti-TU3A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
