| Host: | Rabbit |
| Applications: | WB/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 400 Mu g-600 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Fadd |
| Gene ID: | 14082 |
| Uniprot ID: | FADD_MOUSE |
| Immunogen Region: | 1-205 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of mouse FADD (NP_034305.1). |
| Immunogen Sequence: | MDPFLVLLHSLSGSLSGNDL MELKFLCRERVSKRKLERVQ SGLDLFTVLLEQNDLERGHT GLLRELLASLRRHDLLQRLD DFEAGTATAAPPGEADLQVA FDIVCDNVGRDWKRLARELK VSEAKMDGIEEKYPRSLSER VRESLKVWKNAEKKNASVAG LVKALRTCRLNLVADLVEEA QESVSKSENMSPVLRDSTVS SSETP |
| Function | Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. |
| Protein Name | Fas-Associated Death Domain ProteinFas-Associating Death Domain-Containing ProteinMediator Of Receptor Induced Toxicity |
| Database Links | Reactome: R-MMU-140534Reactome: -MMU-2562578Reactome: -MMU-3371378Reactome: -MMU-5218900Reactome: -MMU-5357786Reactome: -MMU-5357905Reactome: -MMU-5675482Reactome: -MMU-69416Reactome: -MMU-75157Reactome: -MMU-75158 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Fas-Associated Death Domain Protein antibodyAnti-Fas-Associating Death Domain-Containing Protein antibodyAnti-Mediator Of Receptor Induced Toxicity antibodyAnti-Fadd antibodyAnti-Mort1 antibody |
Information sourced from Uniprot.org
