Anti-FADD antibody (1-205) (STJ11103241)

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STJ11103241
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Host: Rabbit
Applications: WB/IF/ICC/IP/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IF/ICC:1:50-1:200
IP:0.5 Mu g-4 Mu g antibody for 400 Mu g-600 Mu g extracts of whole cells
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Fadd
Gene ID: 14082
Uniprot ID: FADD_MOUSE
Immunogen Region: 1-205
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of mouse FADD (NP_034305.1).
Immunogen Sequence: MDPFLVLLHSLSGSLSGNDL MELKFLCRERVSKRKLERVQ SGLDLFTVLLEQNDLERGHT GLLRELLASLRRHDLLQRLD DFEAGTATAAPPGEADLQVA FDIVCDNVGRDWKRLARELK VSEAKMDGIEEKYPRSLSER VRESLKVWKNAEKKNASVAG LVKALRTCRLNLVADLVEEA QESVSKSENMSPVLRDSTVS SSETP
Function Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Protein Name Fas-Associated Death Domain Protein
Fas-Associating Death Domain-Containing Protein
Mediator Of Receptor Induced Toxicity
Database Links Reactome: R-MMU-140534
Reactome: -MMU-2562578
Reactome: -MMU-3371378
Reactome: -MMU-5218900
Reactome: -MMU-5357786
Reactome: -MMU-5357905
Reactome: -MMU-5675482
Reactome: -MMU-69416
Reactome: -MMU-75157
Reactome: -MMU-75158
Alternative Antibody Names Anti-Fas-Associated Death Domain Protein antibody
Anti-Fas-Associating Death Domain-Containing Protein antibody
Anti-Mediator Of Receptor Induced Toxicity antibody
Anti-Fadd antibody
Anti-Mort1 antibody

Information sourced from Uniprot.org