Anti-FADD antibody (1-205) [S2MR] (STJ11103172)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal FADD (1-205) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Fadd |
| Gene ID | 14082 |
| Uniprot ID | FADD_MOUSE |
| Immunogen Region | 1-205 |
| Immunogen Sequence | MDPFLVLLHSLSGSLSGNDL MELKFLCRERVSKRKLERVQ SGLDLFTVLLEQNDLERGHT GLLRELLASLRRHDLLQRLD DFEAGTATAAPPGEADLQVA FDIVCDNVGRDWKRLARELK VSEAKMDGIEEKYPRSLSER VRESLKVWKNAEKKNASVAG LVKALRTCRLNLVADLVEEA QESVSKSENMSPVLRDSTVS SSETP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of mouse FADD (NP_034305.1). |
Additional Info
| Function | Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. |
| Protein Name | Fas-Associated Death Domain ProteinFas-Associating Death Domain-Containing ProteinMediator Of Receptor Induced Toxicity |
| Database Links | Reactome: R-MMU-140534Reactome: -MMU-2562578Reactome: -MMU-3371378Reactome: -MMU-5218900Reactome: -MMU-5357786Reactome: -MMU-5357905Reactome: -MMU-5675482Reactome: -MMU-69416Reactome: -MMU-75157Reactome: -MMU-75158 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Fas-Associated Death Domain Protein antibodyAnti-Fas-Associating Death Domain-Containing Protein antibodyAnti-Mediator Of Receptor Induced Toxicity antibodyAnti-Fadd antibodyAnti-Mort1 antibody |
Information sourced from Uniprot.org