| Function | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs. Modulates prostaglandin E2 secretion. |
| Protein Name | Long-Chain-Fatty-Acid--Coa Ligase 4Arachidonate--Coa LigaseLong-Chain Acyl-Coa Synthetase 4Lacs 4 |
| Database Links | Reactome: R-HSA-434313Reactome: R-HSA-75876 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Type Iii Membrane ProteinPeroxisome MembraneMicrosome MembraneEndoplasmic Reticulum MembraneCell Membrane |
| Alternative Antibody Names | Anti-Long-Chain-Fatty-Acid--Coa Ligase 4 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Long-Chain Acyl-Coa Synthetase 4 antibodyAnti-Lacs 4 antibodyAnti-ACSL4 antibodyAnti-ACS4 antibodyAnti-FACL4 antibodyAnti-LACS4 antibody |
Information sourced from Uniprot.org