| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HAP40 (C-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS + 0.02% NaN3 |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
F8A1.F8A2.F8A3 |
| Gene ID: |
474383/474384/8263 |
| Uniprot ID: |
HAP40_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Reacts with the C-terminal region of human HAP40 protein. |
| Immunogen: |
Synthetic peptide corresponding to amino acids from the C-terminal region of human HAP40 protein. |
| Function | RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility. |
| Protein Name | 40-Kda Huntingtin-Associated ProteinHap40Cpg Island ProteinFactor Viii Intron 22 Protein |
| Cellular Localisation | CytoplasmNucleusEarly EndosomeNuclear BodyDiffuse Presence In The Cytoplasm And Accumulation In The NucleusIn Absence Of HttF8a1/F8a2/F8a3 Is Concentred In CytoplasmColocalized With Htt In EndosomesIn Neuron Found In Intranuclear StructuresThe Intranuclear Rodlets (Inrs)Also Known As Rodlets Of RoncoroniIn Association With Ubiquitin |
| Alternative Antibody Names | Anti-40-Kda Huntingtin-Associated Protein antibodyAnti-Hap40 antibodyAnti-Cpg Island Protein antibodyAnti-Factor Viii Intron 22 Protein antibodyAnti-F8A1.F8A2.F8A3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
