| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | F8 |
| Gene ID: | 2157 |
| Uniprot ID: | FA8_HUMAN |
| Immunogen Region: | 21-300 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-300 of human F8 (NP_000123.1). |
| Immunogen Sequence: | TRRYYLGAVELSWDYMQSDL GELPVDARFPPRVPKSFPFN TSVVYKKTLFVEFTDHLFNI AKPRPPWMGLLGPTIQAEVY DTVVITLKNMASHPVSLHAV GVSYWKASEGAEYDDQTSQR EKEDDKVFPGGSHTYVWQVL KENGPMASDPLCLTYSYLSH VDLVKDLNSGLIGALLVCRE GSLAKEKTQTLHKFILLFAV FDEGKSWHSETKNSLMQDRD AASARAWPKMHTVNGYVNR |
| Post Translational Modifications | Sulfation on Tyr-1699 is essential for binding vWF. Proteolytically cleaved by cathepsin CTSG to produce a partially activated form. |
| Function | Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa. |
| Protein Name | Coagulation Factor ViiiAntihemophilic FactorAhfProcoagulant Component Cleaved Into - Factor Viiia Heavy Chain - 200 Kda Isoform - Factor Viiia Heavy Chain - 92 Kda Isoform - Factor Viii B Chain - Factor Viiia Light Chain |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-163841Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-9672383Reactome: R-HSA-9672387Reactome: R-HSA-9672391Reactome: R-HSA-9672393Reactome: R-HSA-9672395Reactome: R-HSA-9672396Reactome: R-HSA-9672397Reactome: R-HSA-9673202Reactome: R-HSA-9674519 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Coagulation Factor Viii antibodyAnti-Antihemophilic Factor antibodyAnti-Ahf antibodyAnti-Procoagulant Component Cleaved Into - Factor Viiia Heavy Chain - 200 Kda Isoform - Factor Viiia Heavy Chain - 92 Kda Isoform - Factor Viii B Chain - Factor Viiia Light Chain antibodyAnti-F8 antibodyAnti-F8C antibody |
Information sourced from Uniprot.org