| Post Translational Modifications | Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Activated protein C inactivates factor V and factor Va by proteolytic degradation. Phosphorylated by FAM20C in the extracellular medium. |
| Function | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
| Protein Name | Coagulation Factor VActivated Protein C CofactorProaccelerin - Labile Factor Cleaved Into - Coagulation Factor V Heavy Chain - Coagulation Factor V Light Chain |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140875Reactome: R-HSA-204005Reactome: R-HSA-381426Reactome: R-HSA-5694530Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Coagulation Factor V antibodyAnti-Activated Protein C Cofactor antibodyAnti-Proaccelerin - Labile Factor Cleaved Into - Coagulation Factor V Heavy Chain - Coagulation Factor V Light Chain antibodyAnti-F5 antibody |
Information sourced from Uniprot.org
