| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-F5 (300-510) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
F5 |
| Gene ID: |
2153 |
| Uniprot ID: |
FA5_HUMAN |
| Immunogen Region: |
300-510 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-510 of human F5 (NP_000121.2). |
| Immunogen Sequence: |
VGPEGKWIISSLTPKHLQAG MQAYIDIKNCPKKTRNLKKI TREQRRHMKRWEYFIAAEEV IWDYAPVIPANMDKKYRSQH LDNFSNQIGKHYKKVMYTQY EDESFTKHTVNPNMKEDGIL GPIIRAQVRDTLKIVFKNMA SRPYSIYPHGVTFSPYEDEV NSSFTSGRNNTMIRAVQPGE TYTYKWNILEFDEPTENDAQ CLTRPYYSDVD |
| Tissue Specificity | Plasma. |
| Post Translational Modifications | Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Activated protein C inactivates factor V and factor Va by proteolytic degradation. Phosphorylated by FAM20C in the extracellular medium. |
| Function | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
| Protein Name | Coagulation Factor VActivated Protein C CofactorProaccelerin - Labile Factor Cleaved Into - Coagulation Factor V Heavy Chain - Coagulation Factor V Light Chain |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140875Reactome: R-HSA-204005Reactome: R-HSA-381426Reactome: R-HSA-5694530Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Coagulation Factor V antibodyAnti-Activated Protein C Cofactor antibodyAnti-Proaccelerin - Labile Factor Cleaved Into - Coagulation Factor V Heavy Chain - Coagulation Factor V Light Chain antibodyAnti-F5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
