| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Coagulation factor XI (491-540 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
F11 |
| Gene ID: |
2160 |
| Uniprot ID: |
FA11_HUMAN |
| Immunogen Region: |
491-540 aa |
| Specificity: |
This antibody detects endogenous levels of FA11 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human FA11 at the amino acid range 491-540 |
| Post Translational Modifications | N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite. Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. Activated by F12 (activated).the presence of negatively charged surfaces accelerates activation. Activated by F2 (thrombin).the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, strongly accelerates activation. Autoactivated.the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, accelerates autoactivation and autolysis. |
| Function | Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. |
| Protein Name | Coagulation Factor XiFxiPlasma Thromboplastin AntecedentPta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-9673221 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Coagulation Factor Xi antibodyAnti-Fxi antibodyAnti-Plasma Thromboplastin Antecedent antibodyAnti-Pta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain antibodyAnti-F11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
