| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Ezrin/villin 2 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-3.75µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
EZR |
| Gene ID: |
7430 |
| Uniprot ID: |
EZRI_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_003370.2 |
| Immunogen Sequence: |
QDYEEKTKKAER |
| Post Translational Modifications | Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. |
| Function | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. |
| Protein Name | EzrinCytovillinVillin-2P81 |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-437239Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Apical Cell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionMicrovillus MembraneRuffle MembraneCytoplasmCell CortexCytoskeletonMicrovillusLocalization To The Apical Membrane Of Parietal Cells Depends On The Interaction With Pals1Localizes To Cell Extensions And Peripheral Processes Of AstrocytesMicrovillar Peripheral Membrane Protein (Cytoplasmic Side) |
| Alternative Antibody Names | Anti-Ezrin antibodyAnti-Cytovillin antibodyAnti-Villin-2 antibodyAnti-P81 antibodyAnti-EZR antibodyAnti-VIL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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