| Tissue Specificity | Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. |
| Post Translational Modifications | Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. |
| Function | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. |
| Protein Name | EzrinCytovillinVillin-2P81 |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-437239Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Apical Cell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionMicrovillus MembraneRuffle MembraneCytoplasmCell CortexCytoskeletonMicrovillusLocalization To The Apical Membrane Of Parietal Cells Depends On The Interaction With Pals1Localizes To Cell Extensions And Peripheral Processes Of AstrocytesMicrovillar Peripheral Membrane Protein (Cytoplasmic Side) |
| Alternative Antibody Names | Anti-Ezrin antibodyAnti-Cytovillin antibodyAnti-Villin-2 antibodyAnti-P81 antibodyAnti-EZR antibodyAnti-VIL2 antibody |
Information sourced from Uniprot.org
