| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | N-glycosylated. |
| Function | Glycosyltransferase forming with EXT2 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling. |
| Protein Name | Exostosin-1Exostosin Glycosyltransferase 1Heparan Sulfate Co-Polymerase Subunit Ext1Multiple Exostoses Protein 1N-Acetylglucosaminyl-Proteoglycan 4-Beta-Glucuronosyltransferase |
| Database Links | Reactome: R-HSA-2022928Reactome: R-HSA-3656237Reactome: R-HSA-3656253 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusCis-Golgi Network MembraneEndoplasmic Reticulum MembraneThe Active Heparan Sulfate Polymerase Complex Composed Of Ext1 And Ext2 Is Localized To The Golgi ApparatusIf Both Proteins Are Individually Detected In The Endoplasmic ReticulumThe Formation Of The Complex Promotes Their Transport To The Golgi |
| Alternative Antibody Names | Anti-Exostosin-1 antibodyAnti-Exostosin Glycosyltransferase 1 antibodyAnti-Heparan Sulfate Co-Polymerase Subunit Ext1 antibodyAnti-Multiple Exostoses Protein 1 antibodyAnti-N-Acetylglucosaminyl-Proteoglycan 4-Beta-Glucuronosyltransferase antibodyAnti-EXT1 antibody |
Information sourced from Uniprot.org
