| Host: |
Rabbit |
| Applications: |
WB/IHC/ELISA |
| Reactivity: |
Human |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Exosome Complex Component Rrp45 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: |
Antigen affinity purification |
| Concentration: |
1.02 mg/mL |
| Dilution Range: |
WB 1:500-1:2000, IHC 1:40-1:200 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. |
| Protein Name | Exosome Complex Component Rrp45Autoantigen Pm/Scl 1Exosome Component 9P75 Polymyositis-Scleroderma Overlap Syndrome-Associated AutoantigenPolymyositis/Scleroderma Autoantigen 1Polymyositis/Scleroderma Autoantigen 75 KdaPm/Scl-75 |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-429958Reactome: R-HSA-450385Reactome: R-HSA-450513Reactome: R-HSA-450604Reactome: R-HSA-6791226 |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasmColocalizes With Setx In Nuclear Foci Upon Induction Of Transcription-Related Dna Damage At The S PhaseIsoform 1: NucleusIsoform 2: NucleusIsoform 3: NucleusExcluded From The Nucleolus |
| Alternative Antibody Names | Anti-Exosome Complex Component Rrp45 antibodyAnti-Autoantigen Pm/Scl 1 antibodyAnti-Exosome Component 9 antibodyAnti-P75 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen antibodyAnti-Polymyositis/Scleroderma Autoantigen 1 antibodyAnti-Polymyositis/Scleroderma Autoantigen 75 Kda antibodyAnti-Pm/Scl-75 antibodyAnti-EXOSC9 antibodyAnti-PMSCL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
