| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EXOSC8 (1-276) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EXOSC8 |
| Gene ID: |
11340 |
| Uniprot ID: |
EXOS8_HUMAN |
| Immunogen Region: |
1-276 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human EXOSC8 (NP_852480.1). |
| Immunogen Sequence: |
MAAGFKTVEPLEYYRRFLKE NCRPDGRELGEFRTTTVNIG SISTADGSALVKLGNTTVIC GVKAEFAAPSTDAPDKGYVV PNVDLPPLCSSRFRSGPPGE EAQVASQFIADVIENSQIIQ KEDLCISPGKLVWVLYCDLI CLDYDGNILDACTFALLAAL KNVQLPEVTINEETALAEVN LKKKSYLNIRTHPVATSFAV FDDTLLIVDPTGEEEHLATG TLTIVMDEEGKLCCLHKPG |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs. |
| Protein Name | Exosome Complex Component Rrp43Exosome Component 8Opa-Interacting Protein 2Oip-2Ribosomal Rna-Processing Protein 43P9 |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-429958Reactome: R-HSA-450385Reactome: R-HSA-450513Reactome: R-HSA-450604Reactome: R-HSA-6791226 |
| Cellular Localisation | CytoplasmNucleusNucleolus |
| Alternative Antibody Names | Anti-Exosome Complex Component Rrp43 antibodyAnti-Exosome Component 8 antibodyAnti-Opa-Interacting Protein 2 antibodyAnti-Oip-2 antibodyAnti-Ribosomal Rna-Processing Protein 43 antibodyAnti-P9 antibodyAnti-EXOSC8 antibodyAnti-OIP2 antibodyAnti-RRP43 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
