| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EXO5 |
| Gene ID: | 64789 |
| Uniprot ID: | EXO5_HUMAN |
| Immunogen Region: | 1-373 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-373 of human EXO5 (NP_073611.1). |
| Immunogen Sequence: | MAETREEETVSAEASGFSDL SDSEFLEFLDLEDAQESKAL VNMPGPSSESLGKDDKPISL QNWKRGLDILSPMERFHLKY LYVTDLATQNWCELQTAYGK ELPGFLAPEKAAVLDTGASI HLARELELHDLVTVPVTTKE DAWAIKFLNILLLIPTLQSE GHIREFPVFGEGEGVLLVGV IDELHYTAKGELELAELKTR RRPMLPLEAQKKKDCFQVSL YKYIFDAMVQGKVTPASLI |
| Function | Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting.however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. |
| Protein Name | Exonuclease VExo VHexo5Defects In Morphology Protein 1 Homolog |
| Cellular Localisation | NucleusCytoplasmCytosolLocalizes To Repair Foci In Response To Dna Damage |
| Alternative Antibody Names | Anti-Exonuclease V antibodyAnti-Exo V antibodyAnti-Hexo5 antibodyAnti-Defects In Morphology Protein 1 Homolog antibodyAnti-EXO5 antibodyAnti-C1orf176 antibodyAnti-DEM1 antibody |
Information sourced from Uniprot.org