| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EXO5 (1-373) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EXO5 |
| Gene ID: |
64789 |
| Uniprot ID: |
EXO5_HUMAN |
| Immunogen Region: |
1-373 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-373 of human EXO5 (NP_073611.1). |
| Immunogen Sequence: |
MAETREEETVSAEASGFSDL SDSEFLEFLDLEDAQESKAL VNMPGPSSESLGKDDKPISL QNWKRGLDILSPMERFHLKY LYVTDLATQNWCELQTAYGK ELPGFLAPEKAAVLDTGASI HLARELELHDLVTVPVTTKE DAWAIKFLNILLLIPTLQSE GHIREFPVFGEGEGVLLVGV IDELHYTAKGELELAELKTR RRPMLPLEAQKKKDCFQVSL YKYIFDAMVQGKVTPASLI |
| Function | Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting.however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. |
| Protein Name | Exonuclease VExo VHexo5Defects In Morphology Protein 1 Homolog |
| Cellular Localisation | NucleusCytoplasmCytosolLocalizes To Repair Foci In Response To Dna Damage |
| Alternative Antibody Names | Anti-Exonuclease V antibodyAnti-Exo V antibodyAnti-Hexo5 antibodyAnti-Defects In Morphology Protein 1 Homolog antibodyAnti-EXO5 antibodyAnti-C1orf176 antibodyAnti-DEM1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
