| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-EVC2/Limbin (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: A customer reported that a consistent band was observed in 293 and human heart at approx 75kDa with 1 hour incubation of primary at 0.5ug/ml.IHC: In paraffin embedded Human Placen |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | EVC2 |
| Gene ID: | 132884 |
| Uniprot ID: | LBN_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_667338.3; NP_001159608.1 |
| Specificity: | This antibody is expected to recognise isoform 1 (NP_667338.3) and isoform 2 (NP_001159608.1). |
| Immunogen Sequence: | LNAKKAMRALGMD |
| Function | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis. |
| Protein Name | LimbinEllis-Van Creveld Syndrome Protein 2Evc2 |
| Database Links | Reactome: R-HSA-5632684Reactome: R-HSA-5635838 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmCytoskeletonCilium Basal BodyCell ProjectionCiliumCilium MembraneNucleusThe Evc Complex Localizes At The Base Of Cilia In The Evc Zone Of Primary Cilia In A Efcab7-Dependent Manner |
| Alternative Antibody Names | Anti-Limbin antibodyAnti-Ellis-Van Creveld Syndrome Protein 2 antibodyAnti-Evc2 antibodyAnti-EVC2 antibodyAnti-LBN antibody |
Information sourced from Uniprot.org
