Anti-ETV6 antibody (1-300) (STJ118114)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ETV6 (1-300) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ETV6 |
| Gene ID | 2120 |
| Uniprot ID | ETV6_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MSETPAQCSIKQERISYTPP ESPVPSYASSTPLHVPVPRA LRMEEDSIRLPAHLRLQPIY WSRDDVAQWLKWAENEFSLR PIDSNTFEMNGKALLLLTKE DFRYRSPHSGDVLYELLQHI LKQRKPRILFSPFFHPGNSI HTQPEVILHQNHEEDNCVQR TPRPSVDNVHHNPPTIELLH RSRSPITTNHRPSPDPEQRP LRSPLDNMIRRLSPAERAQG PRPHQENNHQESYPLSVSP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_001978.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression. |
| Function | Transcriptional repressor.binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. |
| Protein Name | Transcription Factor Etv6Ets Translocation Variant 6Ets-Related Protein Tel1Tel |
| Database Links | Reactome: R-HSA-9673768Reactome: R-HSA-9703465 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Etv6 antibodyAnti-Ets Translocation Variant 6 antibodyAnti-Ets-Related Protein Tel1 antibodyAnti-Tel antibodyAnti-ETV6 antibodyAnti-TEL antibodyAnti-TEL1 antibody |
Information sourced from Uniprot.org