| Tissue Specificity | Expressed in keratinocytes. |
| Post Translational Modifications | Sumoylated.enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2. |
| Function | Transcriptional activator. May play a role in keratinocyte differentiation. (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator.the core-binding sequence is 5'-ACGGAATGT-3'. |
| Protein Name | Ets Translocation Variant 4Adenovirus E1a Enhancer-Binding ProteinE1a-FPolyomavirus Enhancer Activator 3 HomologProtein Pea3 |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ets Translocation Variant 4 antibodyAnti-Adenovirus E1a Enhancer-Binding Protein antibodyAnti-E1a-F antibodyAnti-Polyomavirus Enhancer Activator 3 Homolog antibodyAnti-Protein Pea3 antibodyAnti-ETV4 antibodyAnti-E1AF antibodyAnti-PEA3 antibody |
Information sourced from Uniprot.org
