| Host: | Rabbit |
| Applications: | WB/IP/ELISA/ChIP |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IP:0.5 Mu g-4 Mu g antibody for 400 Mu g-800 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. ChIP:5 Mu g anti |
| Gene Symbol: | ETV1 |
| Gene ID: | 2115 |
| Uniprot ID: | ETV1_HUMAN |
| Immunogen Region: | 1-100 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ETV1 (NP_004947.2). |
| Immunogen Sequence: | MDGFYDQQVPYMVTNSQRGR NCNEKPTNVRKRKFINRDLA HDSEELFQDLSQLQETWLAE AQVPDNDEQFVPDYQAESLA FHGLPLKIKKEPHSPCSEIS |
| Tissue Specificity | Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and peripheral blood leukocytes. |
| Post Translational Modifications | Sumoylated. Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5.phosphorylation activates transcriptional activity. |
| Function | Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGAAT-3'. Required for olfactory dopaminergic neuron differentiation.may directly activate expression of tyrosine hydroxylase (TH). |
| Protein Name | Ets Translocation Variant 1 Ets-Related Protein 81 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ets Translocation Variant 1 antibody Anti-Ets-Related Protein 81 antibody Anti-ETV1 antibody Anti-ER81 antibody |
Information sourced from Uniprot.org