| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Persulfide dioxygenase ETHE1, mitochondrial is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ETHE1 |
| Gene ID: |
23474 |
| Uniprot ID: |
ETHE1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of ETHE1 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human ETHE1 |
| Function | Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus. |
| Protein Name | Persulfide Dioxygenase Ethe1 - MitochondrialEthylmalonic Encephalopathy Protein 1Hepatoma Subtracted Clone One ProteinSulfur Dioxygenase Ethe1 |
| Database Links | Reactome: R-HSA-1614517 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Matrix |
| Alternative Antibody Names | Anti-Persulfide Dioxygenase Ethe1 - Mitochondrial antibodyAnti-Ethylmalonic Encephalopathy Protein 1 antibodyAnti-Hepatoma Subtracted Clone One Protein antibodyAnti-Sulfur Dioxygenase Ethe1 antibodyAnti-ETHE1 antibodyAnti-HSCO antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
