| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-ETEA/UBXD8 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.3-1µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
FAF2 |
| Gene ID: |
23197 |
| Uniprot ID: |
FAF2_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_055428.1 |
| Immunogen Sequence: |
HTEVLFVQDLTDE |
| Function | Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly. |
| Protein Name | Fas-Associated Factor 2Ubx Domain-Containing Protein 3bUbx Domain-Containing Protein 8 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8980692 |
| Cellular Localisation | CytoplasmLipid DropletEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Fas-Associated Factor 2 antibodyAnti-Ubx Domain-Containing Protein 3b antibodyAnti-Ubx Domain-Containing Protein 8 antibodyAnti-FAF2 antibodyAnti-ETEA antibodyAnti-KIAA0887 antibodyAnti-UBXD8 antibodyAnti-UBXN3B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
