| Post Translational Modifications | N-glycosylated. The Cys-94/Cys-99 and Cys-394/Cys-397 disulfide bonds constitute the redox-active center. The Cys-94/Cys-99 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys-394/Cys-397. The regulatory Cys-99/Cys-104 disulfide bond stabilizes the other regulatory bond Cys-94/Cys-131. Phosphorylated on Ser-145 by FAM20C in the Golgi which increases its enzymatic activity. Phosphorylation is induced by lactation. It is also induced by hypoxia and reductive stress. |
| Function | Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. |
| Protein Name | Ero1-Like Protein AlphaEro1-LEro1-L-AlphaEndoplasmic Oxidoreductin-1-Like ProteinEndoplasmic Reticulum Oxidoreductase AlphaOxidoreductin-1-L-Alpha |
| Database Links | Reactome: R-HSA-3299685 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinLumenal SideGolgi Apparatus LumenSecretedCell ProjectionDendriteThe Association With Erp44 Is Essential For Its Retention In The Endoplasmic ReticulumIn NeuronsIt Localizes To Dendrites |
| Alternative Antibody Names | Anti-Ero1-Like Protein Alpha antibodyAnti-Ero1-L antibodyAnti-Ero1-L-Alpha antibodyAnti-Endoplasmic Oxidoreductin-1-Like Protein antibodyAnti-Endoplasmic Reticulum Oxidoreductase Alpha antibodyAnti-Oxidoreductin-1-L-Alpha antibodyAnti-ERO1A antibodyAnti-ERO1L antibodyAnti-UNQ434 antibodyAnti-PRO865 antibody |
Information sourced from Uniprot.org
