| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Serine/threonine-protein kinase/endoribonuclease IRE2 (841-890 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ERN2 |
| Gene ID: | 10595 |
| Uniprot ID: | ERN2_HUMAN |
| Immunogen Region: | 841-890 aa |
| Specificity: | IRE1 Alpha/Beta Polyclonal Antibody detects endogenous levels of IRE1 Alpha/Beta protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ERN2 at the amino acid range 841-890 |
| Function | Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. |
| Protein Name | Serine/Threonine-Protein Kinase/Endoribonuclease Ire2Endoplasmic Reticulum-To-Nucleus Signaling 2Inositol-Requiring Protein 2Hire2pIre1-BetaIre1b Includes - Serine/Threonine-Protein Kinase - Endoribonuclease |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase/Endoribonuclease Ire2 antibodyAnti-Endoplasmic Reticulum-To-Nucleus Signaling 2 antibodyAnti-Inositol-Requiring Protein 2 antibodyAnti-Hire2p antibodyAnti-Ire1-Beta antibodyAnti-Ire1b Includes - Serine/Threonine-Protein Kinase - Endoribonuclease antibodyAnti-ERN2 antibodyAnti-IRE2 antibody |
Information sourced from Uniprot.org